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Updated: Jul 14, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

タイロシンキナーゼタンパク質基質をATP結合によって高親和性リガンドに変換する

Kui Shen1, Philip A Cole

  • 1Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.

Journal of the American Chemical Society
|December 25, 2003
PubMed
まとめ

研究者は,高親和性Src-ATP結合体を生成することによって,タンパク質キナーゼの相互作用を研究する方法を開発しました. この半合成タンパク質は,複雑な混合物からその結合パートナーであるCskを選択的に捕獲することを可能にします.

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