関連する実験動画

Updated: Jul 9, 2026

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling
08:51

Applying an Inducible Expression System to Study Interference of Bacterial Virulence Factors with Intracellular Signaling

Published on: June 25, 2015

細菌のペニシリン結合タンパク質のDD-トランスペプチダース活性を標的とするメカニズムベースの阻害剤

Mijoon Lee1, Dusan Hesek, Maxim Suvorov

  • 1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.

Journal of the American Chemical Society
|December 25, 2003
PubMed
まとめ

新しいセファロスポリン誘導体である化合物6は,DD-トランスペプチダースに特異的に設計された最初の阻害剤です. バクテリアの細胞壁合成における重要な酵素であるPBP1bを不可逆的に抑制しますが,PBP5.5には影響しません.

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Overview
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Inhibitors of Bacterial DNA Synthesis

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