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Updated: Jul 17, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

非常に強力な非核酸アデノシンデアミナーゼ阻害剤:意図的な鉛混合化による効率的な薬剤発見

Tadashi Terasaka1, Takayoshi Kinoshita, Masako Kuno

  • 1Medicinal Chemistry Research Laboratories, Basic Research Laboratories, and Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6, Kashima, Yodogawa-ku, Osaka 532-8514, Japan.

Journal of the American Chemical Society
|January 8, 2004
PubMed
まとめ

研究者は,2つの異なる分子リードを組み合わせることで,強力な非核酸化アデノシンデアミナーゼ (ADA) 阻害剤を急速に発見しました. この薬剤発見アプローチは,治療開発のための新しい化学物質の識別を加速します.

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