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Updated: Jul 10, 2026

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サイトクロームP450酵素におけるヒドロペロキシ鉄種による水酸化

R Esala P Chandrasena1, Kostas P Vatsis, Minor J Coon

  • 1Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA.

Journal of the American Chemical Society
|January 8, 2004
PubMed
まとめ

この研究では,シトクロームP450酵素によって触媒化された水酸化反応を,動的同位体効果を用いて調査した. 結果は,P450のヒドロキシル化メカニズムにおける2つの異なる同位素に敏感なステップを示唆し,2つの酸化物質モデルをサポートしています.

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