閉経後のホルモン療法の全国的な使用: 年間傾向と最近の証拠への対応
Adam L Hersh1, Marcia L Stefanick, Randall S Stafford
1Stanford Prevention Research Center, Program on Prevention Outcomes and Practices, Stanford University School of Medicine, Stanford, Calif 94305, USA.
JAMA
|January 8, 2004
まとめ
2002年の試験結果がリスクを明らかにした後,閉経後のホルモン療法の使用は急激に減少しました. 処方箋は著しく減少し,多くの女性がホルモン療法 (HT) の投与量を中止または削減しました.
科学分野:
- 生殖医学は,生殖器医学である.
- 臨床薬理学 臨床薬理学とは
- 公共衛生の動向 公共衛生の動向
背景:
- 閉経後のホルモン療法 (HT) の使用は,認知された健康上の利点のために急増しました.
- 2002年の試験データは,経口エストロゲン/プロゲステンHTと関連した心血管およびその他のリスクを明らかにしました.
研究 の 目的:
- 1995年から2003年7月までのホルモン療法 (HT) の利用の国内動向を分析する.
- HTの処方パターンに対する新しい証拠の影響を評価する.
主な方法:
- National Prescription AuditとNational DiseaseとTherapeutic Indexのデータベースを活用しました.
- 1995年1月から2003年7月までの1年間のHT処方箋と医師の処方箋訪問を追跡しました.
主要な成果:
- HTの処方箋は1999年にピークに達し,2002年半ばまで安定していました.
- 2002年7月以降,経口用エストロゲン/プロゲスチン (Premproなど) の処方箋は著しく減少した (66%).
- 2003年の処方箋数は1995年の水準に近づいており,臨床実務の急速な変化を示唆している.
結論:
- 臨床実務では,HTリスクに関する新たな証拠に迅速に適応することが示されました.
- 2002年半ば以来,かなりの数の患者がホルモン療法の投与量を停止または削減しました.
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