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Updated: Jul 6, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

トランスジェニックRNAiは,H19遺伝子インプリントにおけるCTCFの重要な機能を明らかにした

Andrew M Fedoriw1, Paula Stein, Petr Svoboda

  • 1Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|January 13, 2004
PubMed
まとめ

CCCTC結合因子 (CTCF) タンパク質は,卵細胞成長中のメチル化からH19微分メチル化ドメイン (DMD) を保護する. 卵細胞におけるCTCF欠乏は,卵細胞の発達とH19 DMDメチル化を阻害する.

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