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Updated: Jun 17, 2026

Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions
12:43

Advanced Confocal Microscopy Techniques to Study Protein-protein Interactions and Kinetics at DNA Lesions

Published on: November 12, 2017

DNA複製と修復におけるFEN-1基板特異性とPCNA媒介活性化の構造的基礎

Brian R Chapados1, David J Hosfield, Seungil Han

  • 1Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92122, USA.

Cell
|January 14, 2004
PubMed
まとめ

Flap Endonuclease-1 (FEN-1) と増殖細胞核抗原 (PCNA) は,DNA複製と修復の鍵となっている. 彼らの構造は,PCNAがFEN-1を活性化し,特定の酵素-DNA相互作用を通じてDNA処理を調整する方法を明らかにします.

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