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関連する概念動画

Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...

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関連する実験動画

Updated: Jul 6, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

CCNタンパク質:多機能信号調節器

Bernard Perbal1

  • 1Laboratoire d'Oncologie Virale et Moléculaire, UFR de Biochimie, Université Paris 7-D Diderot, 75005, Paris, France. perbal@ccr.jussieu.fr

Lancet (London, England)
|January 16, 2004
PubMed
まとめ
この要約は機械生成です。

結合組織成長因子 (CCN2) は,肝臓のステラ細胞の細胞粘着因子として作用します. その独特の異形は,LRPに異なった形で結合し,細胞シグナル伝達と生物学的活動に影響を与えます.

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関連する実験動画

Last Updated: Jul 6, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
08:35

Inducible and Reversible Dominant-negative (DN) Protein Inhibition

Published on: January 7, 2019

In Vivo Calcium Imaging in C. elegans Body Wall Muscles
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科学分野:

  • バイオケミストリー バイオケミストリー
  • 細胞生物学 細胞生物学
  • 分子医学は分子医学である.

背景:

  • CCNファミリー (cyr61,ctgf,nov) を含むマトリックスタンパク質は,細胞シグナル伝達,増殖,分化に不可欠です.
  • CCN2 (結合組織成長因子) は,肝臓のステラ細胞の重要な細胞粘着因子として特定されています.
  • 肝臓のステラート細胞は,成長因子βの変容に曝露すると,異なるCCN2異形を生成する.

研究 の 目的:

  • 肝臓のステラート細胞におけるCCN2イソフォームの細胞粘着特性を調査する.
  • 低密度リポプロテイン受容体関連タンパク質 (LRP) に結合する特定のCCN2モジュールの役割を明らかにする.
  • CCN2イソフォームのLRPへの差異的結合が,生物学的活動とシグナル伝達にどのように影響するかを理解する.

主な方法:

  • 肝臓のステラ細胞によるCCN2イソフォーム生成の分析.
  • LRPとのCCN2モジュール相互作用の特徴.
  • CCN2とLRPのヘパリン依存結合機構の調査.

主要な成果:

  • CCN2は,肝臓のステラ細胞の細胞粘着因子として作用します.
  • CCN2モジュール3は,LRPへのヘパリン依存結合を媒介する.
  • CCN2モジュール4は,LRPから独立した粘着を促進します.
  • CCN2イソフォームのLRPへの差異的結合は,文脈に依存するアゴニスティックまたはアンタゴニスティック活動を示唆しています.

結論:

  • CCN2イソフォームの特定の構成は,その生物学的活動と生物学的利用可能性に影響を与えます.
  • CCN2の多機能性の構造的基礎を理解することは,分子医学におけるその応用にとって不可欠です.
  • 断片化されたCCNイソフォームの生産メカニズムに関するさらなる研究は不可欠です.