嗅覚:人間の汗の匂いを嗅ぐ蚊の受容体

Elissa A Hallem¹, A Nicole Fox, Laurence J Zwiebel

¹Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.

Nature

|January 16, 2004

まとめ

メスアノフェレス蚊は,匂いを用いて人間を検出する. 研究者らは,ヒトの汗に反応する雌蚊の特定のオドラント受容体,AgOr1を特定し,マラリアベクトルを制御する新しい方法を提案した.

科学分野:

分子生物学は分子生物学である.
エントモロジーエントモロジー学
神経科学は神経科学である.

背景:

アノフェレス蚊は,プラズモディウム・ファルシパラムのマラリアを伝播し,世界の健康に重大な負担を及ぼしています.
雌蚊の宿主探しの行動は,嗅覚のヒントに大きく依存しているが,その基礎となる分子機構はほとんど不明のままである.

研究の目的:

女性アノフェレス蚊の嗅覚認識の分子基礎を調査する.
ヒト宿主の検出に関与する特定の匂い受容体を特定するために.

主な方法:

アノフェレス・ガンビアの嗅覚受容体の特徴 AgOr1.1.
人間の汗を含む様々な化学化合物に対する受容体の反応を評価するための電気生理学的記録.

主要な成果:

アノフェレス・ガンビアのタンパク質であるAgOr1は,雌にのみ存在し,推定におい受容体として特定されました.
AgOr1は,人間の汗に含まれる成分に対する特定の反応を示した.

結論:

AgOr1は,雌アノフェレス蚊によるヒト宿主の嗅覚検出に重要な役割を果たしています.
AgOr1受容体を特定の化合物で標的にすることは,トラップと駆逐剤の吸引剤を含む蚊の制御のための新しい戦略につながる可能性があります.

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