心肺バイパス手術中の心筋梗塞および心筋梗塞の保存
R M Engelman1, S Levitsky, M J O'Donoghue
1Department of Surgery, The Abraham Lincoln School of Medicine, The University of Illinois at the Medical Center, Chicago, USA.
Circulation
|September 1, 1978
まとめ
多用量カリウム心不全と併合した低温症は,心停止および再注射の間に十分な心筋保存を提供します. 低体温停止のみまたはノルモテルミア時の心臓麻痺を含む他の方法は,最適な心臓保護には不十分であることが示されました.
科学分野:
- 心臓病学 心臓病学
- 心血管外科手術についてです.
- 実験医学は,実験医学である.
背景:
- 発血停止を含む心臓外科手術の際には,心筋節の保存が非常に重要です.
- 保存技術の最適化により,イシュケミア-再輸血による損傷が軽減されます.
- 低体温症と心臓麻痺は一般的ですが,精細化が必要です.
研究 の 目的:
- 低体温とカリウム心変性による心筋梗塞の保存における有効性を評価する.
- 低体温症,心筋麻痺,ペルファゼットの様々な組み合わせを比較するために.
- 長期のイシュケミア中に心臓を保護するための最適なプロトコルを決定する.
主な方法:
- 豚の心臓のインビボ製剤で120分の不血性停止と30分間の再注入.
- 7つの実験グループは,異なる保存戦略を評価した.
- 測定された主要パラメータ:心筋収縮性,コンプライアンス,血流量.
主要な成果:
- 低体温停止は心臓麻痺なく,心臓麻痺停止は正常体温で,保存が不十分であった.
- 血中パルファサートと単一投与の心臓麻痺は改善したが,不十分な結果を示した.
- 多用量カリウム (35mEq/L) による低体温と心筋麻痺のみが,収縮性129%と従順性の向上により,十分な心筋保存を達成しました.
結論:
- 低体温と併合した多用量カリウム心症は,効果的な心筋膜の保護に不可欠です.
- 低体温停止や正常体温性心不全などの単純な方法は不十分です.
- この研究は,手術中に心臓機能を保存するための最適なプロトコルを特定しています.
関連する概念動画
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