発血後再注射中のカルシウム投与が心筋の収縮性,硬さ,腫れ,超構造に及ぼす影響
T J Bixler1, J T Flaherty, T J Gardner
1Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Circulation
|September 1, 1978
まとめ
心停止後にカルシウムを投与すると,心臓の機能が改善され,さらなる損傷を引き起こすことなく腫れが軽減されます. この発見は,再注射療法中の心筋細胞の保護を理解するために極めて重要です.
科学分野:
- 心臓病学 心臓病学
- 細胞生物学 細胞生物学
- バイオケミストリー バイオケミストリー
背景:
- 発血後および再注射後の心筋細胞損傷におけるカルシウムの役割は,現在調査中です.
- 低熱性血栓停止は,心機能障害と細胞損傷につながる可能性があります.
研究 の 目的:
- カルシウム投与が心筋収縮性および低熱性缺血性停止および再注血後の損傷に及ぼす影響を調査する.
- カルシウムの潜在力を評価し,心臓の手続きで使用されるシトラートベースの溶液の悪影響を軽減する.
主な方法:
- 血液に浸透したイソヴォルミックの犬の心臓製剤 (n=26) を利用した.
- 犬を4つのグループに分けました. ノルモカルセミックコントロール,カルシウム塩化物 (CaCl2) 投与,チラート・フォスファート・デクストロース (CPD) 投与,CPDとCaCl2の併用投与.
- 左心室の収縮性,心筋の硬さ,細胞/亜細胞損傷,および再注血後の心筋腫を評価した.
主要な成果:
- カルシウム投与 (IIグループ) は,左心室の収縮性を改善し,心臓筋の硬さを増加させたが,対照群 (Iグループ) に比べて追加の細胞損傷を引き起こさなかった.
- サイトレート (CPD) の投与 (III グループ) は収縮性を低下させ,心筋腫を増加させた.
- カルシウムとシトレートの併用投与 (グループIV) は,シトレート誘発の収縮性低下を逆転させ,腫れを最小限に抑え,硬さを増加させ,追加の形態学的損傷を及ぼさなかった.
結論:
- 再注入から15分後に投与されたカルシウムは,低熱性血栓停止後の心臓の収縮性を改善します.
- カルシウム投与は,シトレートの悪影響を相殺し,心臓のケアに潜在的な利点を提供することができます.
- カルシウムは,心筋梗塞の損傷を悪化させることなく,心臓機能の改善のための安全な治療薬であるようです.
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