灼傷後の皮膚におけるビタミンDの合成
Gordon L Klein1, Tai C Chen, Michael F Holick
1Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555-0352, USA. gklein@utmb.edu
Lancet (London, England)
|January 31, 2004
まとめ
重度の火傷は,子供にビタミンDの欠乏を引き起こし,骨の健康に影響を及ぼします. ビタミンDサプリメントは,火傷の回復後のこれらの欠陥に対処するために推奨されます.
科学分野:
- バイオケミストリー バイオケミストリー
- 皮膚科 皮膚科について
- 小児科は小児科です.
背景:
- 重度の火傷は,ビタミンD欠乏,骨の転化障害,およびカルシウム不均衡と関連しています.
- 現在の臨床実務では,常時ビタミンDサプリメントを投与したり,日焼け患者の日焼けをコントロールしたりしていません.
研究 の 目的:
- 重度の火傷による子供の皮膚におけるビタミンD前駆体変換を調査する.
- 小児の灼熱の生存者における血清25-ヒドロキシビタミンDレベルを評価するために.
主な方法:
- ビタミンD3前駆体に対する皮膚バイオプシーのサンプル分析.
- 7-デヒドロコレステロールからプレビタミンD3への変換に対する紫外線B光の影響の測定.
- 血清25-ヒドロキシビタミンD濃度の定量化.
主要な成果:
- 7デヒドロコレステロールのプリビタミンD3への変換の有意な減少は,子どもでは,平均して14ヶ月後に観察されました.
- 低血清25-ヒドロキシビタミンD濃度が研究集団で検出されました.
結論:
- 皮膚におけるビタミンD前駆物質の変換は,重度の火傷による重傷の後に障害がある.
- ビタミンD欠乏症は,小児の灼熱の生存者における持続的な問題です.
- 常規のビタミンDサプリメントは,重度の火傷から回復している子供に示されています.
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