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Updated: Jul 16, 2026

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
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EGFRとLIN-12/Notch経路の交差は,C. elegans vulval発達の過程で発生する

Andrew S Yoo1, Carlos Bais, Iva Greenwald

  • 1Integrated Program in Cellular, Molecular, and Biophysical Studies, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 701 West 168th Street, Room 720, New York, NY 10032, USA.

Science (New York, N.Y.)
|January 31, 2004
PubMed
まとめ

C. elegans vulvaの発達において,表皮成長因子受容体-ミトゲン活性化タンパク質キナーゼ (EGFR-MAPK) 経路は,最初はグレード化された誘導信号によって活性化されます. このアクティベーションは,LIN-12/Notch経路によって制御される新しいネガティブレギュレータによって正確に制御されます.

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