冠動脈疾患の患者のリスクマーカーとして尿中の8-イソプロスタグランジンF2α:マッチした症例対照試験
Edzard Schwedhelm1, Asja Bartling, Henrike Lenzen
1Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg-Eppendorf, Germany. schwedhelm@uke.uni-hamburg.de
Circulation
|February 6, 2004
まとめ
8-イソプロスタグランジンF2α (8-イソ-PGF2α) の上昇によって示される全身の酸化ストレスは,冠動脈性心疾患 (CHD) と関連しています. このマーカーは,C反応性タンパク質とともに,独立してCHDリスクを予測します.
科学分野:
- 心血管研究 循環器科の研究
- バイオマーカー バイオマーカー
- オキシダティブ・ストレスは,
背景:
- 酸化ストレスが動脈硬化と糖尿病,高血圧,肥満,喫煙などの主要なCHDリスク要因に役割を果たしています.
- この研究では,心血管疾患の危険因子と全身性酸化ストレスレベルとの関連を調査した.
研究 の 目的:
- 心臓病のリスク要因が,全身の酸化ストレスの増加と相関しているという仮説を検証する.
- 冠動脈疾患のリスク評価のための新しいバイオマーカーを特定する.
主な方法:
- 年齢と性別を合わせた93人の心臓病患者と93人の対照群を対象としたケース・コントロール研究.
- 尿中の8-イソ-プロスタグランジンF2アルファ (8-イソ-PGF2アルファ) とその代謝産物をガス染色体-タンデム質量スペクトロメトリを用いて測定する.
- BMI,血圧,C反応性タンパク質,HDLコレステロールを含む臨床パラメータの分析.
主要な成果:
- CHDの患者は,対照群と比較して,より高いBMI,シストリック血圧,C反応性タンパク質,尿中の8-iso-PGF2αレベルを示した.
- 尿中の8-イソ-PGF2αおよびその代謝産物の排泄は,心臓病患者において有意に上昇した (P<0.001).
- 多変量分析では,8-イソ-PGF2αとC反応性タンパク質の上昇は,それぞれ30.8と7.2の確率比で,心臓病の独立した予測因子でした.
結論:
- 8-イソプロスタグランジンF2α (8-イソ-PGF2α) は,冠動脈疾患 (CHD) の敏感で独立したリスクマーカーです.
- 尿中の8-イソ-PGF2αレベルは,従来のCHDリスク因子の数と相関しています.
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