コミュニティにおけるフローメディエイトの膨張の臨床的相関値と遺伝性:フレミングハム心臓研究
Emelia J Benjamin1, Martin G Larson, Michelle J Keyes
1Evans Department of Medicine, Boston University School of Medicine, Framingham Study, Boston, Mass 01702-5827, USA. emelia@bu.edu
Circulation
|February 11, 2004
まとめ
腕動脈の流動媒介拡張 (FMD) によって測定される内皮機能は,年齢,高血圧,BMI,喫煙とともに低下する. 前回の運動と心拍数は,よりよいFMDと関連していた. 遺伝性は控えめでした.
科学分野:
- 心血管の健康について
- 血管生物学 血管生物学
- エピデミオロジー エピデミオロジー
背景:
- 内皮機能の障害は,選択された集団における心血管疾患と関連しています.
- 内皮機能の臨床的相関性および遺伝性に関するコミュニティレベルのデータは不足しています.
研究 の 目的:
- コミュニティサンプルにおける内皮機能の臨床的相関性を調査する.
- 内皮機能の遺伝性を推定する.
主な方法:
- 超音波を用いた2883人の参加者において,腕動脈の流動媒介拡張 (FMD%) を評価した.
- 多変数回帰を使用して,FMD%に関連する要因を特定しました.
- FMDの推定遺伝率%.
主要な成果:
- FMD%は,年齢,シストリック血圧,BMI,脂質低下薬,喫煙と逆に関連していました.
- FMD%は女性の性別,心拍数,および前回の6分間ウォーキングテストのパフォーマンスと正に関連していました.
- FMDの推定遺伝率は0.14.%でした.
結論:
- 年齢,血圧,BMI,喫煙は,コミュニティにおける内皮機能の低下と関連しています.
- 運動と心拍数は,内皮機能の改善と関連している可能性があります.
- 内皮機能の遺伝性は控えめで,遺伝的および環境的要因に関するさらなる研究が必要である.
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