C反応性タンパク質と年齢関連の黄斑変性との関連
Johanna M Seddon1, Gary Gensler, Roy C Milton
1Epidemiology Unit, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Mass 02114, USA. Johanna_Seddon@meei.harvard.edu
JAMA
|February 12, 2004
まとめ
高濃度のC反応性タンパク質 (CRP) は,年齢関連の黄斑変性 (AMD) を発症するリスクの増加と関連しています. この発見は,炎症がAMD発症に役割を果たすことを示唆しています.
科学分野:
- オフタルモロジック (眼科)
- 炎症の研究 炎症の研究
- 心血管疾患のリスク因子 心血管疾患のリスク因子
背景:
- C反応性タンパク質 (CRP) は,全身性炎症の主要なマーカーです.
- 特定の心血管疾患 (CVD) の危険因子は,年齢関連の黄斑変性 (AMD) の危険因子と重複する.
- CRPとAMDのリスクとの関連は,以前は確立されていなかった.
研究 の 目的:
- 高濃度のC反応性タンパク質 (CRP) と,年齢関連の黄斑変性 (AMD) の発生リスクとの関連を調査する.
主な方法:
- 年齢関連の眼疾患研究 (AREDS) の930人の参加者を対象としたケース・コントロール研究です.
- 参加者は, fundus写真の格付けに基づいて,AMDのないグループ,軽度,中間,および高度なAMDに分類されました.
- 断食中の血液サンプルを分析して,高感度CRPレベルを調べました.
主要な成果:
- CRPレベルは,AMDのない人と比較して,進んだAMDの個人に著しく高かった (中位は3.4対2.7mg/L).
- 高濃度のCRPは,混同要因を調整した後に,中期および進行期AMDと独立して関連していた.
- 進行性AMDの確率比は,CRPレベルが高くなり,特に最高四分位および90パーセント位で増加しました.
結論:
- 高濃度のCRPは,年齢関連の黄斑変性 (AMD) の独立した危険因子です.
- これらの発見は,AMDの潜在的病原性における炎症を意味しています.
- CRPは,AMDリスク評価の潜在的なバイオマーカーとして機能する可能性があります.
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