白人と東アジア人の子供におけるウィルムズ腫瘍の表遺伝子の違い
Ryuji Fukuzawa1, Norman E Breslow, Ian M Morison
1Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand.
Lancet (London, England)
|February 14, 2004
まとめ
ウィルムズ腫瘍の発生率は,IGF2インプリントの違いにより,民族によって異なります. 東アジアの子供たちは,白人の患者に共通するメカニズムであるIGF2におけるインプリントの喪失 (LOI) を稀に見出します.
科学分野:
- 遺伝学 遺伝学とは
- エピジェネティクス エピジェネティクス
- 小児腫瘍学 小児腫瘍学
背景:
- ウィルムスの腫瘍発生率における国際的変動は,遺伝的影響を示唆している.
- インスリン型の成長因子2 (IGF2) 遺伝子は通常インプリントされていますが,インプリントの喪失 (LOI) はいくつかの腫瘍で起こり,バイアレル発現につながります.
- この研究では,IGF2 LOIの頻度の違いが,東アジアと白人の子供の発生率の違いを説明するかどうかを調査しています.
研究 の 目的:
- IGF2インプリント喪失 (LOI) によるウィルムズ腫瘍の比率の変動が,東アジアと白人の子供の間の異なる発生率を説明できるかどうかを判断する.
- 異なる民族集団におけるウィルムズ腫瘍におけるIGF2 LOIおよび関連ペリロバル腎性休息の頻度を比較する.
主な方法:
- IGF2エクソン9のApaIポリモルフィズムまたはDNAメチル化のための定量PCRを使用してIGF2LOIを評価しました.
- 日本人,白人,東アジア人の子供からのウィルムスの腫瘍におけるペリロバル腎性休息の頻度を組織学的に評価した.
主要な成果:
- IGF2 LOIは,白人の子供のウィルムズ腫瘍 (13/41) で観察されたが,日本の子供 (0/21) では観察されなかった.
- ペリロバル腎性休息は,白人のアメリカ人子供 (24%),日本人の子供 (1%) および東アジア系アメリカ人の子供 (8%) と比較して,白人のアメリカ人子供 (24%),東アジア系アメリカ人の子供 (8%) で著しく頻繁でした.
結論:
- 東アジア人群におけるウィルムズ腫瘍は,白人の患者によく見られるIGF2 LOIメカニズムから発生することは稀である.
- 日本人および東アジア系アメリカ人の子供におけるIGF2 LOIおよび関連する休息の低頻度は,これを支持しています.
- この表遺伝的メカニズムの頻度の変動は,人口間で異なるウィルムスの腫瘍発生率の説明を提供します.
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