アシンプトティック・デンタル・スコアと冠動脈疾患の有病率

Sok-Ja Janket¹, Markku Qvarnström, Jukka H Meurman

¹Department of General Dentistry, Boston University Goldman School of Dental Medicine, 100 E. Newton St, Boston, Mass 02118, USA. sjanket@hsph.harvard.edu

Circulation

|February 18, 2004

まとめ

口腔の健康は冠動脈性心疾患 (CHD) を予測する可能性がある. 新しい歯科スコア (ADS) は,他の要因と組み合わせて,心血管疾患の予測を改善し,口腔の健康を示唆しました.

科学分野:

口腔健康と心血管疾患の研究.
病気の病原性における炎症のバイオマーカー.

背景:

口腔感染症と炎症は,冠動脈疾患 (CHD) の病原化に関連しています.
口腔病理学からのサイトカイン生成は,心血管疾患の危険に寄与する可能性があります.

研究の目的:

冠動脈性心疾患 (CHD) を予測するための新しい口腔健康スコアを開発し,検証する.
経口炎症メディエーターがCHDリスク予測モデルを改善できるかどうかを評価する.

主な方法:

アシンプトティック・デンタル・スコア (ADS) を開発し,256人のフィンランドのCHD患者と250人の対照群でロジスティック回帰を用いた.
虫歯,歯周炎,歯周炎などの歯の要因を調べました.
トータル・デンタル・インデックスと既知のCHD予測指標に対して,検証されたADS.

主要な成果:

C反応性タンパク質,HDL,およびフィブリノゲンを含むADSモデルは,フレミングハム心臓スコア (0.80) と比較すると,優れたまたは等しい説明能力 (C統計=0.82) を示しました.
ADSをモデルから削除すると,予測力が著しく低下しました (C統計は0.77になりました).

結論:

アシンプトティック・デンタル・スコア (ADS) は,積極的な心臓評価のための貴重な予備検査ツールとして役立つかもしれません.
口腔健康スコアがインシデントCHDの予測指標であることを確認するために,さらなる見通し研究が必要である.

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