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Updated: Jul 14, 2026

Xenopus laevis as a Model to Identify Translation Impairment
10:24

Xenopus laevis as a Model to Identify Translation Impairment

Published on: September 27, 2015

eIF4AIIIを含む複合体は,mRNAの局所化とナンセンス媒介のmRNAの衰退に必要なものです

Isabel M Palacios1, David Gatfield, Daniel St Johnston

  • 1Wellcome Trust/Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

Nature
|February 20, 2004
PubMed
まとめ

この研究では,トランスレーション開始因子eIF4AIIIとBarentszが,ハエのmRNA局所化における重要な構成要素として特定されています. これらのタンパク質は,ヒト細胞のナンセンス媒介 mRNA 崩壊 (NMD) にも重要な役割を果たし,保存された機能を明らかにします.

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Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells08:47

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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