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Updated: Jul 31, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

哺乳類のSIRT1はフォークヘッドの転写因子を抑制する

Maria Carla Motta1, Nullin Divecha, Madeleine Lemieux

  • 1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|February 26, 2004
PubMed
まとめ

哺乳類のSIRT1は,Foxo3aのようなフォークヘッド因子を脱酸化し,その活動を抑制し,アポトーシスを減少させます. これは酵母と虫と対照的に,カロリー制限が長寿を促進する方法を説明する可能性がある.

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