関連する実験動画
Updated: Apr 27, 2026

09:39
The Trier Social Stress Test Protocol for Inducing Psychological Stress
Published on: October 19, 2011
56.9K
血管新生因子と抗アポプトシス因子の分泌は,人間の脂肪系ストロマル細胞によって行われます
Jalees Rehman1, Dmitry Traktuev, Jingling Li
1Krannert Institute of Cardiology, Indiana Center for Vascular Biology & Medicine, Indianapolis, Ind 46202, USA.
Circulation
|March 3, 2004
まとめ
皮下脂肪系ストロマル細胞 (ASC) は,心血管疾患治療の有望な源である. これらの細胞は血管の成長と生存を促進し,血管新生を促進するための新しい治療の選択肢を提供します.
科学分野:
- 再生医学は,再生医療である.
- 心血管科学の研究について
- 細胞療法 細胞療法
背景:
- 心血管疾患の治療では,血管新生を促進するために,自律的な細胞伝達を探求しています.
- 限られた細胞数は,現在の細胞ベースの治療法の有効性を妨げる可能性があります.
- 皮下脂肪からのアディポス・ストロマル細胞 (ASC) は,新しい,アクセス可能な細胞源を提供します.
研究 の 目的:
- 治療目的の血管新生源としてのヒト皮下脂肪からの非脂肪細胞ストロマル細胞の可能性を調査する.
- ASCの成長因子分泌プロフィールを特徴づける.
- ASCの血管新生性および抗アポプトシス効果をインビトロおよびインビボで評価する.
主な方法:
- 人間の皮下脂肪系ストロマル細胞 (ASC) の分離とフローサイトメトリによる特徴付け.
- ASCによる成長因子分泌量 (VEGF,HGF,TGF-β) の定量化,ノルモキシクおよびヒポキシク条件下.
- 内皮細胞の増殖とアポトーシスに対する条件媒体の影響の評価.
- 筋血性後肢のマウスモデルにおけるASCのインビボ評価.
主要な成果:
- ASCは,相当量のVEGF,HGF,TGF-βを分泌する.
- 低酸素とVEGF遺伝子感染は,ASCからのVEGF分泌を著しく増加させた.
- 低酸素ASCからの条件付け媒体は,内皮細胞の成長を促進し,アポトーシスを減少させた.
- ヒトASC治療は,後肢不全症のマウスの血液 perfusion を著しく改善しました.
結論:
- 皮下ASCは,シナギスティックなプロアンジオジェニック成長因子の分泌により,血管新生および抗アポプトティックな潜在能力を有する.
- 低酸素によって調節されるネイティブまたはトランスデュースされたASCは,血管新生を促進するための新しい治療戦略を表しています.
- これらの発見は,心血管の保護と再生のために自律的なASCの使用を支持します.
関連する概念動画
Self-Evaluation: Self-Enhancement and Self-Verification
4.7K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
4.7K
General State of Stress
916
The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
916
Ethnic Identity within a Larger Culture
412
Adolescents from ethnic minority backgrounds face a multifaceted journey in forming their identities, shaped by the intersections of cultural expectations and personal exploration. For these adolescents, identity formation involves not only typical developmental challenges but also navigating the perceptions and attitudes of the majority culture. As they grow, adolescents in ethnic minority groups often become increasingly aware of stereotypes, social biases, and discrimination, all of which...
412
Introduction to Stress and Lifestyle
861
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
861
Psychological Responses to Stress
976
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
976
Stress and Mental Health
1.7K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
1.7K

