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カロリー制限と乳がんの発生率
Karin B Michels1, Anders Ekbom
1Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA. kmichels@rics.bwh.harvard.edu
JAMA
|March 11, 2004
まとめ
アノレキシア・ネブローサなどのヒトにおける重度のカロリー制限は,侵襲性乳がんのリスクを大幅に減らす可能性があります. この保護効果は,出産前の早期の生活制限でより強く見えます.
科学分野:
- 腫瘍学 腫瘍学
- エンドクリノロジー エンドクリノロジー
- 公衆衛生は公衆衛生である.
背景:
- カロリー制限 (CR) は寿命を延ばし,動物モデルにおける腫瘍発生率を減少させます.
- 癌,特に乳癌のリスクに対するCRの影響に関するヒトの研究は限られている.
- 神経性食欲不全 (AN) は,人生の初期に重度のカロリー制限を伴う.
研究 の 目的:
- アノレキシア・ネブローサによる早期のカロリー制限と,その後の侵襲性乳がんのリスクとの関連性を調査する.
- 出産に関連するカロリー制限のタイミングが乳がんリスクに影響するかどうかを判断する.
主な方法:
- スウェーデンの国家登録 (入院,がん,死亡,生殖能力) を利用した遡及的なコホート研究.
- 40歳未満のアノレキシア神経サで入院した7303人の女性 (1965年-1998年) を含む.
- 既にある癌の診断を受けた女性を除外する.
主要な成果:
- ANのために入院した女性は,一般の人々と比較して,侵襲性乳がんの発生率が53%低いことを示しました.
- ヌリパロスの女性では,ANの発生率が23%低かった.
- ANを持つ女性では,乳がんの発生率がより実質的に76%減少した.
結論:
- ANが例示したヒトにおける重度のカロリー制限は,侵襲性乳がんに対する保護を提供することができる.
- 最初の出産に先立つ早期のカロリー制限,それに続く妊娠は,乳がんのリスクが著しく減少するとの関連があります.
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