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Updated: Jul 9, 2026

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
11:40

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

Published on: April 1, 2014

Mタンパク質は,古典的な細菌の毒性の決定因子であり,フィブリノゲンと複合体を形成し,血管の漏れを誘導します

Heiko Herwald1, Henning Cramer, Matthias Mörgelin

  • 1Department of Cell and Molecular Biology, Lund University, Tornavägen 10, S-221 84 Lund, Sweden. heiko.herwald@medkem.lu.se

Cell
|March 16, 2004
PubMed
まとめ

Streptococcus pyogenes Mタンパク質はフィブリノゲンと結合し,中性粒子を活性化し,血管の漏れや重症疾患を引き起こす媒介体を放出します. この相互作用を遮断すると,損傷が防止され,毒性ショック症候群の重要なメカニズムが強調されます.

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