1型糖尿病の小児における内皮機能不全と動脈内側介質の厚さの増加

Mikko J Järvisalo¹, Maria Raitakari, Jyri O Toikka

¹Department of Clinical Physiology, University of Turku, Turku, Finland. mikko.jarvisalo@utu.fi

Circulation

|March 17, 2004

まとめ

1型糖尿病の小児は,しばしば内皮機能の障害を示し,減少したフローメディアテッド膨張 (FMD) によって示されます. この機能障害は,動脈硬化症の初期症状,特に大動脈の内側中枢の厚さ (IMT) の増加と関連しています.

科学分野:

小児内分泌学について
心血管研究循環器科の研究
糖尿病・メリトスとは

背景:

内皮機能不全は,第1型糖尿病における動脈硬化症の発達に関与しています.
糖尿病の子供における血管の変化の早期発見は極めて重要です.

研究の目的:

1型糖尿病の小児における血管内皮機能の調査.
内皮機能不全が早期動脈硬化変化と相関するかどうかを判断する.

主な方法:

非侵襲的超音波を用いて,腕動脈の流動媒介膨張 (FMD) と大動脈の内側中枢厚さ (IMT) を評価した.
75人の子どもを対象に,45人が1型糖尿病と30人の健康な対照群を対象に研究を行った.

主要な成果:

1型糖尿病の子どもでは,対照群と比較して,口病が著しく減少し,IMTが増加した.
糖尿病の小児における内皮機能不全 (低 FMD) は,高 carotid IMT と高 LDL コレステロールと関連していました.
多変量分析により,糖尿病,低口腔炎,高LDLコレステロールが,IMT増加の相関値として特定されました.

結論:

FMDの障害は,1型糖尿病の子供において一般的な発見である.
内皮機能不全は,この集団における大動脈IMTの増加と関連しています.
これらの発見は,内皮機能不全による1型糖尿病の小児における早期性動脈硬化症への予備性を示唆しています.

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