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Updated: May 5, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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手術後の痛みに対する患者制御のトランスダーマルフェンタニル水塩化物対静脈注射モルヒンポンプ:ランダム化制御試験

Eugene R Viscusi1, Lowell Reynolds, Frances Chung

  • 1Department of Anesthesiology, Thomas Jefferson University, Philadelphia, Pa 19107, USA. eugene.viscusi@jefferson.edu

JAMA
|March 18, 2004
PubMed
まとめ

患者コントロールされた鎮痛 (PCA) のための新しいフェンタニル経皮システム (Fentanyl transdermal system) は,従来のIVモルヒンPCAと比較して手術後の痛みを軽減します. このイオンフォレティックシステムは,静脈へのアクセスを必要とせずに,同等の有効性と安全性を提供します.

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Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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