薬物投与システム:メインストリームへの入り口
Theresa M Allen1, Pieter R Cullis
1Department of Pharmacology, University of Alberta, Edmonton T6G 2H7, Canada. terry.allen@ualberta.ca
Science (New York, N.Y.)
|March 20, 2004
まとめ
ナノ粒子を用いた薬物投与システム (DDS) は,親腸投与のための薬物特性を強化します. 承認されたDDS製剤と新薬投与への関心は,その治療的可能性を強調しています.
科学分野:
- バイオメディカルエンジニアリング
- ナノテクノロジー ナノテクノロジー
- 薬理学 薬理学とは
背景:
- 粒子の薬物投与システム (DDS) は,臨床応用において課題に直面しています.
- 脂質およびポリマーベースのナノ粒子は,親腸内投与のための改善された薬物特性を提供します.
- 抗がんおよび抗真菌薬のためのいくつかのDDS製剤は,臨床的に承認されています.
研究 の 目的:
- 薬剤投与システムの進歩と応用をレビューする.
- 新しい治療法のためのDDSの可能性を強調する.
- リンガンド標的療法におけるDDSの使用について議論する.
主な方法:
- ナノ粒子ベースの薬物投与システムに関する既存の文献のレビュー.
- 承認された臨床DDS製剤の分析.
- プロテオミクス,ゲノミクス,および標的型療法における新興アプリケーションの探索.
主要な成果:
- 粒子DDS.の初期の課題を克服するうえで,著しい進展がみられた.
- 承認されたDDS製剤は,これらのシステムの臨床的有効性を証明しています.
- 新薬候補薬および標的型投与のためのDDSの利用に対する関心が高まっている.
結論:
- 薬物投与システム,特にナノ粒子ベースのシステムは,著しく成熟しました.
- DDSは,親腸投与薬の有効性および安全性を高めるために不可欠です.
- DDSの将来の応用は,パーソナライズド医療と先進的な治療法において有望である.
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