シナプス特異性は,シナプスガイドポストタンパク質SYG-2とその受容体SYG-1によって生成されます
Kang Shen1, Richard D Fetter, Cornelia I Bargmann
1Howard Hughes Medical Institute, Department of Anatomy, The University of California, San Francisco, San Francisco, CA 94143, USA.
Cell
|March 24, 2004
まとめ
この研究は,SYG-2を,C. elegans. の神経接続を導く重要なタンパク質として特定しています. SYG-2は,モーターニューロンHSNLを特定のシナプスを形成するように指示し,適切な神経回路の形成を保証します.
科学分野:
- 神経科学は神経科学である.
- 発達生物学 発達生物学とは
- 分子生物学は分子生物学である.
背景:
- シナプス接続は神経系の機能に不可欠であり,正確なターゲティングが必要です.
- ガイドポスト細胞と細胞粘着分子は,シナプス形成を指揮する役割を果たします.
研究 の 目的:
- C. elegans. のシナプスガイドポスト信号の分子成分を特定する.
- モーターニューロンのHSNLシナプス形成を誘導するSYG-2の役割を明らかにする.
主な方法:
- C. elegans. の syg-1 と syg-2 ミュータントの遺伝子解析
- SYG-2の発現とSYG-1の局所化の免疫ヒストケミカル分析.
- 異なる細胞タイプにおけるSYG-2の誤発現の研究.
主要な成果:
- SYG-2は,超膜免疫グロブリン族のタンパク質で,シナプスガイドポスト信号として作用します.
- SYG-2は,HSNLモーターニューロン上のSYG-1に結合し,シナプス形成を促進します.
- SYG-1またはSYG-2の突然変異はシナプス特異性を破壊し,正しいシナプスが少なく,子宮外シナプスが多くなります.
- SYG-2の誤った発現は,異常なSYG-1とシナプスマーカーの蓄積を誘導する.
結論:
- SYG-2は,HSNL運動ニューロンにおけるシナプス特異性を確立するために不可欠です.
- SYG-2やSYG-1のような免疫グロブリン超家族タンパク質の間の局所的な相互作用が,発達中のシナプス標的を決定する.
さらに関連する動画
07:51Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
Published on: November 14, 2014
09:33An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
Published on: June 26, 2018
関連する概念動画
01:12Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
02:47The Synapse
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
01:09Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
01:26Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
01:26Chemical Synapses
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
01:32Postsynaptic Potential (PSP)
Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...