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Updated: Jul 23, 2026

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation
08:47

Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation

Published on: March 5, 2018

PIDDソームは,遺伝子毒性ストレスへの反応としてカスパース-2の活性化に関与するタンパク質複合体です

Antoine Tinel1, Jürg Tschopp

  • 1Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

Science (New York, N.Y.)
|April 10, 2004
PubMed
まとめ

この研究では,ストレス誘発性アポトーシスの重要な役割を果たすカスパース-2を活性化するタンパク質複合体を特定しました. PIDDとRAIDDを含むこの複合体は,遺伝子毒性ストレスとp53によって引き起こされるアポトーシスの調節に不可欠です.

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