後期発作は,その後の脳卒中の予測因子である
Paul Cleary1, Simon Shorvon, Raymond Tallis
1Brownlee Centre, Gartnavel General Hospital, Glasgow, UK.
Lancet (London, England)
|April 15, 2004
まとめ
高齢期の発作は,脳卒中のリスクを大幅に高めます. この研究では,60歳以降に再発発作を経験する個人が,その後の脳卒中のリスクがほぼ3倍高いことを発見しました.
科学分野:
- 神経学 神経学とは
- エピデミオロジー エピデミオロジー
- ゲリアトリクス ゲリアトリクス
背景:
- 脳血管疾患は,晩年のの既知の原因である.
- 新発発作と高齢者の脳卒中リスクとの関連は十分に理解されていません.
研究 の 目的:
- 脳卒中歴のない60歳以上の人の新発作が,将来の脳卒中のリスクの増加と関連しているという仮説を検証する.
主な方法:
- 英国の一般医療研究データベースの研究では,新たに発作した4709人の患者 (年齢60歳以上) と4709人の対照群を対象とした.
- 排除基準には,以前の脳血管疾患,脳損傷,腫瘍,薬物乱用,または認知症が含まれていました.
- 患者の記録は,その後の脳卒中診断のために分析されました.
主要な成果:
- ログランクテストは,グループ間の脳卒中なし生存率の非常に有意な差異 (p<0.0001) を明らかにした.
- コックスのモデルでは,対照群と比較して,発作グループにおける脳卒中の相対リスクは2.89 (95%CI 2.45-3.41) と推定された.
結論:
- 人生の終わりに発作の発生は,脳卒中リスクの大幅な増加と関連しています.
- 生命の末期に発作を起こした患者の脳卒中を予防するための介入を評価するために,さらなる研究が必要である.
関連する概念動画
01:43Sex Linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
01:18Factors Affecting Illness
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
For instance, risk factors are connected to illness, disability,...
01:26Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
01:24Disorders of the Female Reproductive System
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
01:29Psychological and Sociocultural Causes of Schizophrenia
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...