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関連する概念動画

What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Reporter Genes02:11

Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
Commonly used reporter...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...

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関連する実験動画

Updated: Jul 1, 2026

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
12:44

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

配列から遺伝子発現を予測する.

Michael A Beer1, Saeed Tavazoie

  • 1Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Cell
|April 16, 2004
PubMed
まとめ
この要約は機械生成です。

この研究は,遺伝子発現ルールを解読する全ゲノム的な方法を導入し,DNA配列と規制要素を分析することによって遺伝子パターンを正確に予測します. このアプローチは,酵母と虫の遺伝子調節を統制する複雑な論理を明らかにしています.

さらに関連する動画

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
07:09

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

関連する実験動画

Last Updated: Jul 1, 2026

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
12:44

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
07:09

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq

Published on: May 28, 2021

科学分野:

  • ゲノミクスとシステム生物学
  • 計算生物学とバイオインフォマティクス

背景:

  • 遺伝子発現は,DNA配列要素を含む複雑な組み合わせコードによって制御される.
  • これらの規制ルールを理解することは,細胞の行動と機能を解読する上で極めて重要です.

研究 の 目的:

  • 組み合わせ遺伝子調節コードの学習のための系統的,全ゲノムアプローチを開発し,適用する.
  • 文脈依存の転写制御を決定するDNA配列要素とその制約を特定する.
  • 推論された規制ルールを用いて遺伝子発現パターンを予測する.

主な方法:

  • 局所的なDNA配列要素を特定するために,確率的,全ゲノムアプローチが採用されました.
  • 分析は,転写調節におけるこれらの要素の位置的および組合せ的制約に焦点を当てた.
  • マイクロアレイの発現データと上流の遺伝子配列が予測モデリングに使用されました.

主要な成果:

  • 推論された規制規則は,Saccharomyces cerevisiaeの遺伝子発現パターンを予測するのに73%の精度を達成しました.
  • このシステムは,Caenorhabditis elegans.の時間的な遺伝子発現を制御する予測的規制要素と組み合わせ規則を特定しました.
  • 複雑な論理 (AND,OR,NOT) で,モチーフの強さ,方向性,位置に制約があり,予測に成功するために必要でした.

結論:

  • この体系的なアプローチは,遺伝子発現の組み合わせコードを成功裏に解読します.
  • このフレームワークは,ゲノム配列からの遺伝子調節を理解するための予測モデルを提供します.
  • 実験的検証のための数多くの仮説を生み出し,細胞動力の研究を進めています.