ピット-1のPOU固有のドメインの変異と, pituitary hypoplasiaなしのhypopituitarismは, pituitary hypoplasiaは, pituitary hypoplasiaは,

R W Pfäffle1, G E DiMattia, J S Parks

  • 1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322.

Science (New York, N.Y.)
|August 21, 1992
PubMed
まとめ

Pit-1転写因子の特定の突然変異は,成長ホルモンとプロラクチン遺伝子の活性化に影響することで,下垂体病を引き起こす. このPit-1変異は,特定の標的遺伝子に選択的に影響を及ぼし,ホルモン欠乏を引き起こす.

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