アルコール摂取と男性における痛風発生リスク:前向きな研究
Hyon K Choi1, Karen Atkinson, Elizabeth W Karlson
1Rheumatology Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. hchoi@partners.org
Lancet (London, England)
|April 20, 2004
まとめ
アルコール摂取は痛風のリスクを大幅に高め,最も危険なのはビールです. 適度なワインの消費は痛風のリスクを高めるようには見えません. この研究は,アルコールと痛風の関連性を前向きに確認しています.
科学分野:
- エピデミオロジー エピデミオロジー
- レウマトロジーの病理学
- 栄養科学 栄養学 栄養科学は,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学が,栄養学は,栄養学が,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は,栄養学は
背景:
- アルコール摂取と痛風のリスクとの関連は,歴史的に疑われてきましたが,将来的に検証されていません.
- 以前の研究では,さまざまな種類のアルコール飲料に関連する痛風リスクを区別することができなかった.
研究 の 目的:
- 大規模な男性コホートにおけるアルコールの消費と発病性痛風の関連性を将来的に調査する.
- 異なるアルコール飲料が,痛風を発症するリスクを異なるものにするかどうかを評価する.
主な方法:
- 12年間の前向きな研究 (1986年-1998年) で,痛風の既往歴のない男性47,150人を対象に実施した.
- 2年に一度のアンケートを使用して,アルコールの消費と痛風症例のデータを収集しました.
- アメリカン・カレッジ・オブ・リウマトロジー (American College of Rheumatology) の調査による痛風の診断基準を用いて,報告された痛風症例を確認した.
主要な成果:
- アルコール消費量の増加は,痛風のリスクの増加と強く関連していた (p for trend <0.0001).
- ビールの消費は,痛風のリスクと最も有意な関連性を示した (RR per 12-oz serving: 1.49).
- また,アルコール飲料の消費は痛風のリスク増加と関連している (RR/飲み物1.15),ワインの消費は関連性がない (RR/4オンス1.04).
結論:
- アルコールの摂取は,痛風を発症させる重要な危険因子です.
- 痛風のリスクは,消費されたアルコールの種類によって大きく異なります.
- ビールの消費は,スピリッツと比較して痛風のリスクが高く,適度なワインの摂取は,このリスクを高めることはありません.
関連する概念動画
Hypothesis Test for Test of Independence
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
H0: The two variables (factors)...
Esophageal Varices-I: Introduction
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Coronary Artery Disease IV: Preventive Measures
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Stress Prevention and Stress Management Techniques IV
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...


