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Updated: Jul 19, 2026

Isolation of Ribosome Bound Nascent Polypeptides in vitro to Identify Translational Pause Sites Along mRNA
10:15

Isolation of Ribosome Bound Nascent Polypeptides in vitro to Identify Translational Pause Sites Along mRNA

Published on: July 6, 2012

哺乳類の細胞では,ピロル・イミダゾールポリアミドをアルキル化することによって,配列特異的な遺伝子サイレンシングが行われます

Ken-Ichi Shinohara1, Akihiko Narita, Takanori Oyoshi

  • 1Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo 101-0062, Japan.

Journal of the American Chemical Society
|April 22, 2004
PubMed
まとめ

N-メチルピロール (Py) -N-メチリミダゾール (Im) ヘアピンポリアミドを用いたシーケンス固有のDNAアルキレーションは,遺伝子発現を効果的に静止させました. これらのポリアミドは,特定の遺伝子発現を標的とした抗腫瘍薬として潜在性を示しています.

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