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Updated: Jul 7, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
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Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

HOXB8 mRNAのマイクロRNA誘導による切断

Soraya Yekta1, I-Hung Shih, David P Bartel

  • 1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

Science (New York, N.Y.)
|April 24, 2004
PubMed
まとめ

マイクロRNA (miRNA) は遺伝子発現を調節する. この研究は,miR-196がHOX遺伝子を標的にし,mRNAの分裂とタンパク質の生産の減少につながり,脊椎動物の新しい遺伝子調節機構を明らかにすることを示しています.

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
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