内皮機能障害と2型糖尿病のリスクのバイオマーカー
James B Meigs1, Frank B Hu, Nader Rifai
1General Medicine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA. jmeigs@partners.org
JAMA
|April 29, 2004
まとめ
E-セレクチンとICAM-1のレベルが上昇すると,女性の2型糖尿病を予測できる. これらの内皮機能不全のバイオマーカーは,肥満や炎症の無い状態でもリスクを示唆します.
科学分野:
- 心血管科学の研究について
- エンドクリノロジー エンドクリノロジー
- エピデミオロジー エピデミオロジー
背景:
- 内皮機能不全は,2型糖尿病と関連しています.
- それは糖尿病の臨床診断に先行するかもしれません.
研究 の 目的:
- 内皮機能不全のプラズマバイオマーカーが,当初非糖尿病の女性における2型糖尿病の発症を予測するかどうかを調査する.
- 評価されたEセレクチン,細胞間粘着分子1 (ICAM-1),および血管細胞粘着分子1 (VCAM-1).
主な方法:
- 看護師の健康研究 (Nurses' Health Study) の内にある将来的な,内蔵された症例対照研究である.
- 血液サンプルを提供した女性32,826人を含め,2000年までに737人が糖尿病を発症した.
- ベースラインバイオマーカーのレベルに基づいてリスクを分析し,複数の共変数に調整した.
主要な成果:
- 糖尿病を発症した女性において,E-セレクチン,ICAM-1,VCAM-1の平均値が著しく高かった.
- EセレクチンとICAM-1の上昇は,2型糖尿病の発生を予測した.
- 調整された相対リスクは,Eセレクチンで5.43,ICAM-1で3.56であった.
結論:
- 内皮機能不全のバイオマーカーは,女性における2型糖尿病を予測する.
- この予測は,肥満やサブクリニカル炎症とは無関係です.
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