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関連する概念動画

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Layers of the Epidermis01:21

Layers of the Epidermis

The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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関連する実験動画

Updated: Jul 5, 2026

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
11:02

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

Published on: August 3, 2011

RETRACTED: バレル皮質の発達におけるマップの可塑性の基礎となる層2/3のシナプス変化

Carl C H Petersen1, Michael Brecht, Thomas T G Hahn

  • 1Department of Cell Physiology, Max-Planck-Institute for Medical Research, Jahnstrasse 29, Heidelberg D-69120, Germany. carl.petersen@epfl.ch

Science (New York, N.Y.)
|May 1, 2004
PubMed
まとめ
この要約は機械生成です。

ネズミのバレルの皮質の発達中の感覚マップの再編成が研究されました. 部分的感覚剥奪は,保護された皮質領域の接続を強化し,保護された領域と保護された領域の間の接続を弱めた.

さらに関連する動画

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

関連する実験動画

Last Updated: Jul 5, 2026

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression
11:02

The Three-Dimensional Human Skin Reconstruct Model: a Tool to Study Normal Skin and Melanoma Progression

Published on: August 3, 2011

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding
09:14

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
08:49

Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale

Published on: May 28, 2021

科学分野:

  • 神経科学は神経科学である.
  • 神経生物学 神経生物学とは
  • 発達神経科学とは

背景:

  • 皮質感覚マップの可塑性は,変化する感覚体験に適応するために不可欠です.
  • 感覚地図における機能的および解剖学的再配置のメカニズムを理解することは,依然として課題です.

研究 の 目的:

  • 部分的感覚欠乏が,発達中のラット・バレル・コーテックスの感覚マップとシナプス結合にどのように影響するかを調査する.
  • 改変された感覚インプットによる皮質柱のインビボおよびインビトロ変異を明らかにする.

主な方法:

  • ネズミのバレルの皮質の発達におけるin vivoおよびin vitroの電気生理学的記録.
  • 部分的感覚喪失後のシナプス結合とニューロン形態の分析.

主要な成果:

  • 欠乏していない皮質の柱は,強化された感覚応答と強化されたシナプス接続性を示した.
  • シナプス接続の確率が増加し,選択的な軸索幹の成長は,隣接し,保存された列のL2/3ピラミッドの間に観察されました.
  • 剥奪されたおよび非剥奪された皮質柱は,弱体化したL2/3ピラミッド接続を示した.

結論:

  • 部分的な感覚的欠乏は,発達中のバレル皮質の重要な機能的および解剖学的再編成を引き起こします.
  • 経験に依存する可塑性は,救われた経路の強化と,恵まれない地域を含む接続の弱化を伴う.
  • これらの発見は,開発中に皮質マップの精錬の基礎となるメカニズムについての洞察を提供します.