ヒドロキシオクタデカディエノアートの酸化分解により,生物学的に活性なガンマ-ヒドロキシアルケナルカルが生成されます
Mingjiang Sun1, Robert G Salomon
1Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44107-7078, USA.
Journal of the American Chemical Society
|May 6, 2004
まとめ
生物体内で豊富に存在するヒドロキシジエンは,ヒドロペロキシドが存在すると,細胞毒性ガマヒドロキシアルケナルを形成するために断片化することができます. この経路は,脂質酸化と疾患発達の理解に極めて重要です.
科学分野:
- バイオケミストリー バイオケミストリー
- リピドミクスは,リピドミクスのことです.
- オキシダティブ・ストレスは,
背景:
- ポリ不飽和脂肪酸 (PUFA) の断片化は,細胞毒性アルデヒドを生成する.
- ガンマ-ヒドロキシアルケータルホルモン (PC) は,生物学的活性があり,疾患に関与しています.
研究 の 目的:
- 常見の in vivo 脂質酸化産物であるヒドロキシディエンの酸化分解を調査する.
- ガンマ-ヒドロキシアルケナルの生成における中間物質としてのヒドロキシディエンの役割を決定する.
主な方法:
- 小型のユニラメラー膀を用いた生理模倣モデル研究を用いた.
- 雇用されたミエロペロキシダゼ誘発のフリーラジカル誘発の断片化.
- ヒドロキシ-およびヒドロペロキシジデンの分解産物を分析した.
主要な成果:
- ヒドロキシジデンは,ヒドロペロキシドの存在下で,ガンマ-ヒドロキシアルケナルに分裂する.
- 9-hydroxy-12-oxododec-10-enoic acid (HODA) エステルHODA-PCの形成が観察されました.
- ハイドロキシディエンは,酸化的に切り離された脂質の生産のために,in vivoでは妥当な中間物質である.
結論:
- ヒドロキシジジエンは,細胞毒性ガマヒドロキシアルケナルのインビボ生成に寄与する.
- ダイオキセタン中間物質の形成は,PUFAの酸化分解には不可欠ではありません.
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