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Updated: Jul 10, 2026

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
19:16

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis

Published on: March 17, 2010

アセチル共酵素aシンタゼに対するZnの作用:カタリシス中のアルファサブユニットにおける構成変化の証拠

Xiangshi Tan1, Matthew R Bramlett, Paul A Lindahl

  • 1Department of Chemistry, Texas A & M University, College Station, Texas 77843, USA.

Journal of the American Chemical Society
|May 13, 2004
PubMed
まとめ

亜鉛 (Zn) は,不活性なニップ金属部位を置換することによって,アセチル-コア合成酶 (ACS) を無効化する. このZn誘発の無活性化は,触媒作用中に発生し,ACSアルファサブユニットの構成の変化が,そのメカニズムにとって決定的であることを示唆しています.

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