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Updated: Jun 19, 2026

Novel RNA-Binding Proteins Isolation by the RaPID Methodology
11:19

Novel RNA-Binding Proteins Isolation by the RaPID Methodology

Published on: September 30, 2016

PAZドメインによるオーバーハング特異的な小干渉RNA認識の構造的基礎

Jin-Biao Ma1, Keqiong Ye1, Dinshaw J Patel1

  • 1Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.

Nature
|May 21, 2004
PubMed
まとめ

PAZドメインによる小干渉RNA (siRNA) エンドバインディングは,RNAサイレンシングに不可欠です. この構造的研究は,PAZがsiRNA複合体を固定し,遺伝子サイレンシング経路を促進する方法を明らかにしています.

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Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

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Different Types of RNA Have the Same Basic Structure
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RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
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RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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