関連する実験動画

Updated: Jul 12, 2026

Generation of Centromere-Associated Protein-E CENP-E-/- Knockout Cell Lines using the CRISPR/Cas9 System
11:49

Generation of Centromere-Associated Protein-E CENP-E-/- Knockout Cell Lines using the CRISPR/Cas9 System

Published on: June 23, 2023

破壊的な精子生成におけるゲノムインプリント

Cristina Joana Marques1, Filipa Carvalho, Mário Sousa

  • 1Department of Genetics, Faculty of Medicine, University of Porto, Porto, Portugal.

Lancet (London, England)
|May 26, 2004
PubMed
まとめ

助産生殖技術は,インプリントする病気を伝達する可能性があります. 精子数が少ない男性からの精子は異常なゲノムインプリントを示し,これらのエラーを伝播するリスクを高めます.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

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Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.