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Increased pulse rate01:17

Increased pulse rate

Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Updated: Jul 9, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

ハイパートロフィック心筋病変症

Perry Elliott1, William J McKenna

  • 1University College London, London, UK.

Lancet (London, England)
|June 9, 2004
PubMed
まとめ
この要約は機械生成です。

ハイパルトロフィック心筋症は,説明不能の左心房高縮を引き起こす遺伝性心疾患であり,結果は変動します. 管理戦略は,遺伝的要因と,最適なケアのための患者特有の条件に依存しています.

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An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
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Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
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Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

関連する実験動画

Last Updated: Jul 9, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

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科学分野:

  • 心臓病学 心臓病学
  • 遺伝学 遺伝学とは
  • 内科内科は,内科の内科である.

背景:

  • ハイパートロフィック心筋症候群 (HCM) は,原因不明の左心室高縮によって特徴づけられる一般的な遺伝性心疾患です.
  • HCMは,無症状の症例から重度の運動不耐性および不律性まで,幅広い臨床的症状のスペクトルを示します.
  • 急性心臓死,心不全,脳卒中を含む疾患の進行と合併症は,遺伝的,病理的,生理学的要因の影響を受け,年間1~2%のリスクを伴う.

研究 の 目的:

  • 原因不明の心筋縮症と診断された患者の管理を見直す.
  • ハイパートロフィック心筋病変症の臨床意思決定を導くために,遺伝的および病理生理学的基質の役割を強調する.

主な方法:

  • ハイパートロフィック心筋病症に関する既存の文献のレビュー.
  • 臨床の経過と結果に影響を与える要因の分析.
  • 患者のサブセットに基づく治療介入の評価.

主要な成果:

  • HCMの臨床経過と予後は,個人によって非常に変動します.
  • 突然死,心不全,脳卒中などの合併症のリスクの分層化は極めて重要ですが,個々の患者の要因に依存します.
  • セプトの切除,ミエクトミー,インプラント可能な心臓変容器-除細動器などの特定の治療介入は,選択された患者グループに示されています.

結論:

  • 遺伝カウンセリングと徹底した臨床リスクの分層化は,HCMを患っているすべての患者にとって不可欠です.
  • 根底にある遺伝的異常や病理生理学的特徴によって情報を得られるパーソナライズされた管理戦略は,多発性心筋症の患者のアウトカムを最適化するための鍵です.