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Updated: Jun 22, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

PRMT1,p300,およびCARM1の配列された協力機能は,p53による転写活性化において

Woojin An1, Jaehoon Kim, Robert G Roeder

  • 1Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA.

Cell
|June 10, 2004
PubMed
まとめ

この研究は,タンパク質アルギニンメチルトランスファーゼPRMT1とCARM1が,p300と共に,直接の相互作用とヒストン改変を通じてp53-依存遺伝子活性化に不可欠であることを明らかにしています. これらのコアクティベーターは,独立して協力して機能し,特定のヒストンのマークを介して遺伝子発現に影響を与えます.

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