長生きドロソフィラは,成人の体脂肪に過剰発現したdFOXOがある

Maria E Giannakou¹, Martin Goss, Martin A Jünger

¹Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.

Science (New York, N.Y.)

|June 12, 2004

まとめ

成人果物ハエのインスリン/インスリン類似成長因子シグナル伝達 (IIS) を減少させると,寿命が延びる. この経路は,この経路です.

科学分野:

老化に関する研究.
分子生物学は分子生物学である.
遺伝学遺伝学とは

背景:

インスリン/インスリン類似成長因子シグナル伝達 (IIS) 経路の活性低下は,種間での寿命の延長と関連しています.
重要な代謝組織である体脂肪は,老化に対するIIS効果の潜在的な仲介者です.

研究の目的:

寿命に対するIIS効果の減少の正確なタイミングを調査する.
老化におけるIISの標的組織としての脂肪体の役割を決定する.

主な方法:

IIS経路のダウンストリームエフェクタであるdFOXOの過剰発現,特に成人ドロソフィラの脂肪体.
dFOXO過剰発現に対する寿命と生育能力の分析.

主要な成果:

大人の脂肪体におけるdFOXOの過剰発現は,雌果物ハエの寿命を大幅に延ばした.
成人の脂肪の体内のIISの減少は,女性の生育能力を低下させましたが,男性の寿命には影響しませんでした.
FOXO転写因子と脂肪組織が老化を調節する役割は,進化的に保存されています.

結論:

成人果物ハエのIIS活性低下は,寿命と生殖能力に影響を与えるのに十分である.
脂肪体とFOXO転写因子は,老化プロセスを調節する上で保存された役割を果たします.

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