構造的に正常な心臓を持つ心房細動の青少年における電気生理学的発見
Kumaraswamy Nanthakumar1, Yung R Lau, Vance J Plumb
1Division of Cardiovascular Diseases, University of Alabama at Birmingham, 1670 University Blvd, B140 Volker Hall, Birmingham AL 35294-0019, USA. kn@crml.uab.edu
Circulation
|June 16, 2004
まとめ
子どもの心房細動 (AF) は,肺静脈または左心房の急激な発火の焦点によって引き起こされる. カテーテルアブレーションは,これらの焦点を効果的に除去し,ほとんどの青少年患者でAFを解決します.
科学分野:
- ペディアトリック・カルディオロジー
- 電気生理学 電気生理学
- 心律不整症とは,心律不整症のこと.
背景:
- 心房細動 (AF) は小児患者ではまれで,その背後にあるメカニズムは不明です.
- 子どもにおけるAFの電気生理学的基礎を理解することは,効果的な治療に不可欠です.
研究 の 目的:
- AFの小児および青少年患者における電気生理学的発見を記述する.
- この集団におけるAFの治療におけるカテーテルアブレーションの有効性を評価する.
主な方法:
- 侵襲的な電気生理学的検査と心内マッピングは,症状のある単一のAFを持つ9人の若者に実施されました.
- カテーテルアブレーションは,特定された自発的なAF発症部位または急激に発火する心房焦点を標的としたものです.
- 複雑な左心房焦点を持つ1人の患者は,外科的な迷宮手術を受けた.
主要な成果:
- AF焦点の最も一般的な起源は,肺静脈 (n=5),左心房 (n=2) およびクリスト・ターミナリス (n=3) でした.
- カテーテル切除は,患者の88.9%で急性成功を達成しました.
- 長期フォローアップでは,患者の77.8%が薬剤なしで心拍動不全状態を維持し,2人の患者は薬剤で制御されたAF再発を経験しました.
結論:
- 構造的に正常な心臓を持つ青少年では,AFは一般的に肺静脈の焦点,左心房,またはcrista terminalisから発生します.
- これらの焦点は,通常,不規則な心房不動脈を誘発します.
- これらの焦点のカテーテル切除は,小児および青少年患者の再発性AFを排除するための効果的な戦略です.
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