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Updated: Jan 9, 2026

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
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Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

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カルシウム放出チャネル (ライオノジン受容体) の漏れに関連した家族性多形心室性心拍動症における突然死

Stephan E Lehnart1, Xander H T Wehrens, Päivi J Laitinen

  • 1Center for Molecular Cardiology, Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, 630 W. 168th St, P&S 9-401, Box 65, New York, NY 10032, USA.

Circulation
|June 16, 2004
PubMed
まとめ

ファミリアルポリモルフィック Ventricular Tachycardia (FPVT) は,RyR2変異が運動誘発性不律症を引き起こすことと関連しています. 薬剤JTV519はRyR2チャネル機能を正常化し,突然の心臓死に対する潜在的な治療を提供しました.

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