ヌクレオシドフォスホリンアンフィフィルの超分子組成
Louis Moreau1, Philippe Barthélémy, Mohamed El Maataoui
1Faculté des sciences d'Avignon 33, rue Louis Pasteur, F-84000 Avignon, France.
Journal of the American Chemical Society
|June 17, 2004
まとめ
新しい尿素のフォスフォコレンのアンフィフィルは,繊維,膀,および水素ゲルなどの様々な超分子構造に自己組み立てます. これらの構造は熱的に可逆性があり,DNAのような治療薬を封じ込めることができます.
科学分野:
- 超分子化学 超分子化学
- マテリアルサイエンス 材料科学
- バイオマテリアル バイオマテリアル
背景:
- ウリジン・フォスフォコリン・アンフィフィルは,薬物投与とバイオ材料における潜在的な応用を持つ新しい分子です.
- 彼らの自己組織化行動を理解することは,機能的な超分子システムを設計する上で極めて重要です.
研究 の 目的:
- ウリジン・フォスホリン・アンフィフィルの新しい家族を合成し,特徴づけること.
- 水性および有機溶液中のこれらの両生性の自己組み立て特性を調査する.
- 治療薬のカプセル化のためのヒドロゲルとオルガノゲルの形成におけるこれらの両生体の可能性を調査する.
主な方法:
- アンフィフィール製剤の4段階の合成経路.
- 微分スキャニングカロメトリー,小角X線散射,UV-VIS,円形二極化スペクトルスコピーを用いた物理化学的特徴付け.
- 光,伝送電子顕微鏡 (TEM),スキャン電子顕微鏡 (SEM) を含む顕微鏡技術.
主要な成果:
- 合成されたアンフィファイルは,自発的に様々な超分子構造に組み合わさります:膀,繊維,水素ゲル,およびオルガノゲル.
- 飽和アルキル鎖を持つアンフィフィルは,結晶状態でDNAのような螺旋状の繊維を形成し,融解温度 (Tm) 以上の二重層を形成する.
- 二重層と繊維の間の熱的に可逆的な移行が観察されました. 6%w/w以上の濃度で形成されるヒドロゲルは,DNAを閉じ込めることができる. オーガノゲルはサイクロヘキサンで形成された.
結論:
- 新しいウリジン・フォスフォコリン・アンフィフィルは,多用途の自己組み立て行動を示し,様々な超分子構造を形成する.
- これらのアンフィフィルは,機能的なヒドロゲルとオルガノゲルの構成要素として,薬物投与システムでの応用の可能性を示しています.
- セルフ・アセンブリの熱的可逆性により,素材の設計に合わせて調整可能な特性を提供します.
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