親の心房細動は,子孫における心房細動の危険因子である

Caroline S Fox¹, Helen Parise, Ralph B D'Agostino

¹National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, Mass 01702-5827, USA. foxca@nhlbi.nih.gov

JAMA

|June 17, 2004

まとめ

親の1人が心房細動 (AF) を患っていると,人生の後半にAFを発症するリスクが著しく増加します. この発見は,この一般的な心律障害に遺伝的要素があることを示唆しています.

科学分野:

心臓病学心臓病学
遺伝学遺伝学とは
エピデミオロジーエピデミオロジー

背景:

心房細動 (AF) は,米国で最も一般的な心不律症です.
稀な家族的な症例は存在するが,一般集団におけるAFの遺伝性は不明である.

研究の目的:

親の心房細動 (AF) が子孫におけるAFのリスク増加と関連しているかどうかを調査する.

主な方法:

Framingham Heart Study (1983-2002) のデータを用いて,前向きなコホート研究が行われました.
AFのない,少なくとも30歳以上の2243人の子孫を分析した.
子孫における新規発症したAFの発症は,親のAFの記録と関連して追跡された.

主要な成果:

2243人の子孫のうち,681人 (30%) の親のうち少なくとも1人がAFを患っていた.
70人の子孫がフォローアップ中にAFを発症しました.
親のうち少なくとも1人がAFを患っていると,子孫にAFを発症するリスクが増加した (OR,1.85;P=.02).
この関連性は,より若い個体や,以前の心臓病のない個体においてより強く見られた.

結論:

親のAFは,子孫にAFを発症させる重要な危険因子です.
これらの発見は,心房細動に対する遺伝的感受性を支持しています.
AFの遺伝的基盤に関するさらなる研究が推奨されています.

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