ゲノム時代の傷害の研究

J Perren Cobb¹, Grant E O'Keefe

¹Cellular Injury and Adaptation Laboratory, Department of Surgery, Washington University in St Louis, St Louis, Missouri 63110, USA. cobb@wustl.edu

Lancet (London, England)

|June 23, 2004

まとめ

技術の進歩により,傷害と敗血症の反応を大規模に分析することができ,死と障害を減らすことを目指しています. この研究は,トラウマ後の合併症を理解するために,ゲノミクスとマルチオミクスを統合しています.

科学分野:

トラウマ・リサーチ・トラウマ・リサーチ
ゲノミクスゲノミクスとは
システム生物学システム生物学

背景:

重度の怪我の生存率は増加しているが,入院感染症と臓器不全により複雑化している.
トラウマ後合併症に関する現在の理解は,データ分析能力によって制限されています.

研究の目的:

傷害と敗血症の全ゲノム分析のための技術的進歩を活用する.
大規模な傷害とセプシスの決定因子と反応を特徴づける.

主な方法:

ゲノム全体の変異 (遺伝子ポリモルフィズム) を調査する.
トランスクリプトームとプロテオームレベルで生物学的反応を特徴づける.
マルチオミックスのデータを臨床フェノタイプと統合する.

主要な成果:

技術の進歩は,データ生成と分析のための新しい機会を提供します.
傷害と結血症を研究するための大規模な共同研究が進行中です.

結論:

新しい技術と既存のアプローチを統合することは極めて重要です.
この研究は,トラウマによる死亡,障害,経済的影響を軽減することを目的としています.

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