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Updated: Apr 30, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
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SCFのようなユビキチン・リガゼ複合体で,プレシナプス分化を制御する

Edward H Liao1, Wesley Hung, Benjamin Abrams

  • 1Department of Medical Genetics and Microbiology, Samuel Lunenfeld Research Institute, University of Toronto, Ontario, Canada M5G 1X5.

Nature
|June 23, 2004
PubMed
まとめ

研究者らは,C. elegansの前シナプスニューロンのシナプス成熟に不可欠なF-ボックスタンパク質であるFSN-1を特定しました. このタンパク質は新しいSCF複合体を形成し,ALKシグナリングをターゲットにすることでシナプスの発達を調節するのに役立ちます.

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