運動に対する血管運動反応に対する冠動脈ブラキセラピーの有害な効果
Mario Togni1, Stephan Windecker, Peter Wenaweser
1Swiss Cardiovascular Center, Inselspital, Bern, Switzerland.
Circulation
|July 1, 2004
まとめ
ステント内静止症に対する冠動脈内ブラキセラピーは,冠動脈における運動による血管拡張を廃止します. ニトログリセリンの反応は維持されているが,これは放射線治療後の内皮機能不全を示唆している.
科学分野:
- 心血管医学は,心臓血管医学である.
- 介入性心臓病学 介入性心臓病学
- 放射線腫瘍学 放射線腫瘍学
背景:
- 冠内ブラキセラピーは,インステントの静止症の治療法として提案されています.
- 血管の整体性や血管運動の反応に対する長期的な影響は不明である.
研究 の 目的:
- 冠動脈内ブラキセラピー後の血管運動反応を測定する.
- 運動中の血管運動に対するブラキセラピーの影響を評価する.
主な方法:
- 静止状態と運動中のバイプレンの定量冠動脈動脈造影.
- ステント置換後の14人の患者 (対照群) と,ステント置換後のレステノシス治療後の13人の患者 (20 Gy) の比較.
- 最小光面,ステント面,基準容器面の分析.
主要な成果:
- 基準血管は,両方のグループで運動による血管拡張を示した.
- ステントセグメント内の血管運動は廃止されました.
- ブラキセラピー群は,対照群とは異なり,近接/遠隔のセグメントで運動誘発性血管収縮を示した.
結論:
- 正常なセグメントは,運動中にフローメディエートされた血管拡張を示します.
- ステントは近辺/遠隔の運動反応に影響を与えない.
- ブラキセラピーは,運動によって引き起こされる血管拡張を排除し,ニトログリセリン反応が保存されているにもかかわらず,内皮機能不全を示す.
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